Authors

Manson, Willett, Stampfer, Colditz, Hunter, Hankinson, Hennekens, & Speizer (1995)²⁸

Conclusion

Individuals with higher BMIs have increased incidence of gallbladder disease and/or cholelithiasis.

Concern

The study did not control for weight cycling. Therefore, the effect of weight loss and/or regain cannot be excluded as a reason for the apparent increase in gallbladder disease evident among large individuals.